Glossary

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Glossary

Glossary

Tissue plasminogen activator (tPA)

Tissue-type plasminogen activator (tPA, TPA) a natural protein, found in the body and able to be manufactured by genetic engineering, that can break up a thrombus. It requires the presence of fibrin as a cofactor and is able to activate plasminogen on the fibrin surface, which distinguishes it from the other plasminogen activators, streptokinase and urokinase. tPAs include reteplase and tenectplase, given to treat acute myocardial infarction, and alteplase.

Unit 6,

Reference: Oxford Concise Colour Medical Dictionary (7th Edition, Kindle Edition) Oxford University Press 2020 ISBN-13: 978-0198836629, p2484

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