Insulin resistance, identified as an impaired biologic response to insulin stimulation of target tissues, primarily involves liver, muscle, and adipose tissue. Impairs glucose disposal, resulting increased beta cell insulin production and hyperinsulinaemia.
Unit 1,
Freeman AM, Acevedo LA, Pennings N. Insulin Resistance. In: StatPearls. Treasure Island (FL): StatPearls Publishing; August 17, 2023.