Cystic fibrosis-related diabetes (CFRD)
Cystic fibrosis-related diabetes (CFRD) is a significant and common co-morbidity associated with cystic fibrosis (CF), affecting 50% of adults with the condition. CF is a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. This mutation leads to the production of thick and sticky mucus, affecting various organs, such as the lungs and pancreas. The impact of CFRD goes beyond the typical complications associated with diabetes. In the context of CF, CFRD contributes to the progression of respiratory issues and worsens overall health. The dehydrated epithelial surfaces caused by mutated CFTR, along with the accumulation of mucus, create an environment conducive to bacterial infections, particularly in the airways and lungs.
Unit 1,
Reference: Kelsey R, Manderson Koivula FN, McClenaghan NH, Kelly C. Cystic Fibrosis-Related Diabetes: Pathophysiology and Therapeutic Challenges. Clin Med Insights Endocrinol Diabetes. 2019;12:1179551419851770. Published 2019 May 28.
